期刊
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
卷 3, 期 -, 页码 135-142出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CCID.S9042
关键词
hydroxy acids; glycolic acid; salicylic acid; UV; erythema; cosmetics
类别
资金
- Intramural Research Program of the National Cancer Institute at NIH
- NATIONAL CANCER INSTITUTE [ZIABC010784] Funding Source: NIH RePORTER
Hydroxy acids (HAs) represent a class of compounds which have been widely used in a number of cosmetic and therapeutic formulations in order to achieve a variety of beneficial effects for the skin. We review and discuss the most frequently used classes of these compounds, such as alpha-hydroxy acids, beta-hydroxy acids, polyhydroxy acids, and bionic acids, and describe their applications as cosmetic and therapeutic agents. Special emphasis is devoted to the safety evaluation of these formulations, in particular on the effects of their prolonged use on sun-exposed skin. Furthermore, we summarize the very limited number of studies dealing with the modifications evoked by topical application of products containing HAs on photocarcinogenesis. In spite of the large number of reports on the cosmetic and clinical effects of HAs, their biological mechanism(s) of action still require more clarification. Some of these mechanisms are discussed in this article along with important findings on the effect of HAs on melanogenesis and on tanning. We also emphasize the important contribution of cosmetic vehicles in these types of studies. Thus, HAs play an important role in cosmetic formulations, as well as in many dermatologic applications, such as in treating photoaging, acne, ichthyosis, rosacea, pigmentation disorders, and psoriasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据