期刊
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 46, 期 1, 页码 1-17出版社
UNIV SAO PAULO, CONJUNTO QUIMICAS
DOI: 10.1590/S1984-82502010000100002
关键词
Mucoadhesion; Bioadhesion; Mucoadhesive systems; Drugs/delivery
资金
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing, the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion. fracture and mechanical. Several in vitro and in vivo methodologies arc proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
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