期刊
BRAZILIAN JOURNAL OF MICROBIOLOGY
卷 45, 期 4, 页码 1409-1413出版社
SPRINGER
DOI: 10.1590/S1517-83822014000400035
关键词
alpha-terpineol; Escherichia coli; antibacterial activity; TEM
类别
资金
- Sichuan Youth Science and Technology Innovation Research Team for waterfowl disease prevention and control [2013TD0015]
- National Natural Science Foundation of China [31372477]
The antibacterial effect of alpha-terpineol from Cinnamomum longepaniculatum (Gamble) N. Chao leaf essential oils were studied with special reference to the mechanism of inhibiting the standard strain of Escherichia coli (CMCC (B) 44102) growth at ultrastructural level. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) and time-kill curves of alpha-terpineol were determined; Escherichia coli was treated with alpha-terpineol and observed under a transmission electron microscope. The MIC and MBC values of alpha-terpineol were all 0.78 mu L/mL, and time-kill curves showed the concentration-dependent. Under the transmission electron microscopy (TEM), Escherichia coli exposed to MIC levels of alpha-terpineol exhibited decreased cell size and irregular cell shape, cell wall and cell membrane were ruptured, nucleus cytoplasm was reduced and nuclear area gathered aside. Results suggest that alpha-terpineol has excellent antibacterial activity and could induce morphological changes of Escherichia coli.
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