期刊
REPRODUCTIVE SCIENCES
卷 17, 期 6, 页码 578-584出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719110364248
关键词
Association study; genome-wide scan; IRM; microsatellites; susceptibility loci
资金
- Chongqing Medical University [0124418029, CX200311]
- China Postdoctoral Science Foundation [2004035527]
- Program for Excellent Talents of University in Chongqing Municipality
The etiology of recurrent miscarriage (RM) is extremely heterogeneous, including genetic, immunologic, anatomic, endocrinological, and infectious anomalies. About 50% of RM is unexplained or poorly understood, which is called idiopathic recurrent miscarriage (IRM). The primary aim of this study was to identify the genetic loci that might be susceptible to IRM. Forty-four Han Chinese patients with IRM during the first trimester of their pregnancies and 44 healthy sex- and ethnic-matched controls were enrolled in this study. A case-control and genome-wide study was performed and 430 polymorphic microsatellite markers were analyzed. Three loci, 6q27 (D6S446, P = .028), 9q33.1 (D9S1776, P = .037), and Xp22.11 (DXS1226, P = .008), significantly associated with IRM were found. This work identified 3 genetic regions that might harbor genes predisposed to IRM and provided new insights for future genetic and etiological study of IRM. Further study is required to confirm it.
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