期刊
BRAIN TOPOGRAPHY
卷 26, 期 1, 页码 98-109出版社
SPRINGER
DOI: 10.1007/s10548-012-0235-0
关键词
Combined EEG-fMRI; Resting state networks; Single-subject; ICA; Dual regression; ECP
资金
- Provincie Gelderland and Overijssel
- ministry of economical affairs
- Advanced Neuro Technology (Enschede, NL)
With combined EEG-fMRI a powerful combination of methods was developed in the last decade that seems promising for answering fundamental neuroscientific questions by measuring functional processes of the human brain simultaneously with two complementary modalities. Recently, resting state networks (RSNs), representing brain regions of coherent BOLD fluctuations, raised major interest in the neuroscience community. Since RSNs are reliably found across subjects and reflect task related networks, changes in their characteristics might give insight to neuronal changes or damage, promising a broad range of scientific and clinical applications. The question of how RSNs are linked to electrophysiological signal characteristics becomes relevant in this context. In this combined EEG-fMRI study we investigated the relationship of RSNs and their correlated electrophysiological signals [electrophysiological correlation patterns (ECPs)] using a long (34 min) resting state scan per subject. This allowed us to study ECPs on group as well as on single subject level, and to examine the temporal stability of ECPs within each subject. We found that the correlation patterns obtained on group level show a large inter-subject variability. During the long scan the ECPs within a subject show temporal fluctuations, which we interpret as a result of the complex temporal dynamic of the RSNs.
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