期刊
BRAIN STRUCTURE & FUNCTION
卷 220, 期 4, 页码 2449-2468出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-014-0800-2
关键词
Hippocampus; Dentate gyrus; GAD; VGAT; VGLUT2; Hypothalamus; SuM
资金
- Institut National de la Sante et de la Recherche Medicale INSERM
- Ligue Francaise Contre l'Epilepsie
- Research Council of Norway
- Centre National de la Recherche Scientifique CNRS
- Institut Federatif de Recherche [IFR131]
In mesial temporal lobe epilepsy (MTLE), spontaneous seizures likely originate from a multi-structural epileptogenic zone, including several regions of the limbic system connected to the hippocampal formation. In this study, we investigate the structural connectivity between the supramammillary nucleus (SuM) and the dentate gyrus (DG) in the model of MTLE induced by pilocarpine in the rat. This hypothalamic nucleus, which provides major extracortical projections to the hippocampal formation, plays a key role in the regulation of several hippocampus-dependent activities, including theta rhythms, memory function and emotional behavior, such as stress and anxiety, functions that are known to be altered in MTLE. Our findings demonstrate a marked reorganization of DG afferents originating from the SuM in pilocarpine-treated rats. This reorganization, which starts during the latent period, is massive when animals become epileptic and continue to evolve during epilepsy. It is characterized by an aberrant distribution and an increased number of axon terminals from neurons of both lateral and medial regions of the SuM, invading the entire inner molecular layer of the DG. This reorganization, which reflects an axon terminal sprouting from SuM neurons, could contribute to trigger spontaneous seizures within an altered hippocampal intrinsic circuitry.
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