期刊
BRAIN STRUCTURE & FUNCTION
卷 219, 期 4, 页码 1355-1367出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-013-0573-z
关键词
Vertigo; Vestibular system; PET; Vestibular neuritis; Visual-vestibular interaction
资金
- German Research Foundation (Deutsche Forschungsgemeinschaft) [Di 379/4-3/4]
- Foundation Stiftung Rheinland-Pfalz fur Innovation [961-386261/759]
- BMBF [01 GW 0642]
- Hertie-Foundation
- Bundesministerium fur Bildung und Forschung (BMBF)
- Deutsche Forschungsgemeinschaft
The human vestibular system is represented in the brain bilaterally, but it has functional asymmetries, i.e., a dominance of ipsilateral pathways and of the right hemisphere in right-handers. To determine if acute right- or left-sided unilateral vestibular neuritis (VN) is associated with differential patterns of brain metabolism in areas representing the vestibular network and the visual-vestibular interaction, patients with acute VN (right n = 9; left n = 13) underwent resting state F-18-FDG PET once in the acute phase and once 3 months later after central vestibular compensation. The contrast acute vs. chronic phase showed signal differences in contralateral vestibular areas and the inverse contrast in visual cortex areas, both more pronounced in VN right. In VN left additional regions were found in the cerebellar hemispheres and vermis bilaterally, accentuated in severe cases. In general, signal changes appeared more pronounced in patients with more severe vestibular deficits. Acute phase PET data of patients compared to that of age-matched healthy controls disclosed similarities to these patterns, thus permitting the interpretation that the signal changes in vestibular temporo-parietal areas reflect signal increases, and in visual areas, signal decreases. These data imply that brain activity in the acute phase of right- and left-sided VN exhibits different compensatory patterns, i.e., the dominant ascending input is shifted from the ipsilateral to the contralateral pathways, presumably due to the missing ipsilateral vestibular input. The visual-vestibular interaction patterns were preserved, but were of different prominence in each hemisphere and more pronounced in patients with right-sided failure and more severe vestibular deficits.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据