期刊
BRAIN STRUCTURE & FUNCTION
卷 216, 期 4, 页码 417-431出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-011-0321-1
关键词
Aging; White matter; Diffusion tensor imaging; Prefrontal cortex; Orbitofrontal cortex
资金
- Canadian Institutes of Health Research (CIHR) [MOP 64413, CIHR MOP 67132]
- Alberta Heritage Foundation for Medical Research (AHFMR)
- Office of the Provost and Vice-President (Academic), University of Alberta
Previous diffusion tensor imaging (DTI) studies confirmed the vulnerability of frontal callosal fibers to normal aging. The present study extended this examination systematically to other prefrontal white matter regions. Structural magnetic resonance imaging and DTI datasets were acquired from 69 healthy subjects aged 22-84 years. The prefrontal white matter was parcellated into several anatomical sub-regions: medial and lateral orbitofrontal white matter, dorsolateral prefrontal white matter, and medial prefrontal white matter, using reliable DTI-tractography protocols. Tract-specific characteristics were calculated using Matlab. Regression models were used to determine the relationship between age and structural integrity of white matter tracts. The results of our study demonstrate regional age-related changes in the prefrontal white matter tracts of the human brain. This study was cross-sectional and therefore additional longitudinal studies are needed to confirm our findings.
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