期刊
BRAIN STIMULATION
卷 7, 期 4, 页码 603-607出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2014.04.007
关键词
Deep brain stimulation; Subthalamic nucleus; Functional magnetic resonance imaging; Nonhuman primate; Motor cortex; Pedunculopontine nucleus
资金
- National Institutes of Health [R01 NS 70872]
- Grainger Foundation
Background: Functional magnetic resonance imaging (fMRI) is a powerful method for identifying in vivo network activation evoked by deep brain stimulation (DBS). Objective: Identify the global neural circuitry effect of subthalamic nucleus (STN) DBS in nonhuman primates (NHP). Method: An in-house developed MR image-guided stereotactic targeting system delivered a mini-DBS stimulating electrode, and blood oxygenation level-dependent (BOLD) activation during STN DBS in healthy NHP was measured by combining fMRI with a normalized functional activation map and general linear modeling. Results: STN DBS significantly increased BOLD activation in the sensorimotor cortex, supplementary motor area, caudate nucleus, pedunculopontine nucleus, cingulate, insular cortex, and cerebellum (FDR < 0.001). Conclusion: Our results demonstrate that STN DBS evokes neural network grouping within the motor network and the basal ganglia. Taken together, these data highlight the importance and specificity of neural circuitry activation patterns and functional connectivity. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.
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