期刊
BRAIN STIMULATION
卷 3, 期 2, 页码 65-77出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2010.01.003
关键词
deep brain stimulation; computational modeling; neural activation; Parkinson's disease
资金
- National Institutes of Health [R01 NS059736, R21 NS050449, F32 NS052042]
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease However. quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited Recently, computational models of varying levels of complexity have been used to study the neural response to DBS The goal of this study was to evaluate the quantitative impact of incrementally incorporating increasing levels of complexity into computer models of STN DBS Out analysis focused on the direct activation of experimentally measureable fiber pathways within the internal capsule (IC) Our model system was customized to an STN DBS pat tent and stimulation thresholds for activation of IC axons were calculated with electric field models that ranged from an electrostatic, homogenous, isotropic model to one that explicitly incorporated the voltage-drop and capacitance of the electrode-electrolyte interface. tissue encapsulation of the electrode, and diffusion-tensor based 3D tissue anisotropy and inhomogeneity The model predictions were compared to experimental IC activation defined from electromyographic (EMG) recordings from eight different muscle groups in the contralateral arm and leg of the STN DBS patient Coupled evaluation of the model and experimental data showed that the most realistic predictions of axonal thresholds were achieved with the most detailed model Furthermore, the more simplistic neurostimulation models substantially overestimated the spatial extent of neural activation (C) 2010 Elsevier Inc All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据