期刊
BRAIN RESEARCH REVIEWS
卷 63, 期 1-2, 页码 39-46出版社
ELSEVIER
DOI: 10.1016/j.brainresrev.2009.11.002
关键词
Synaptogenesis; Neuromuscular junction; Neuroglia; Astrocyte; Schwann cell; Neurodegeneration; Regeneration
资金
- Agence Francaise Contres les Myopathies
- Agence Nationale de la Recherche
- Ara Parseghian Medical Research Foundation
- Centre National de la Recherche Scientifique
- Deutsche Forschungsgemeinschaft
- ELTEM
- European Commission [LSHM-CT-2005-19063]
- Fondation NRJ - Institut de France
- Fondation pour la Recherche Medicale
- Max-Planck Gesellschaft
- Merck-Serono
- Miltenyi Biotech
- Neurex
- Region Alsace
- Retina France
- Sanofi-Aventis
Synaptogenesis is a decisive process for the development of the brain, its plasticity during adulthood and its regeneration after injury and disease. Despite tremendous progress during the last decades, it remains unclear, whether neurons can form synapses autonomously. In this review, I will summarize recent evidence that this is probably not the case and that distinct phases of synapse development depend on help from glial cells. The results supporting this view come from studies on the central and peripheral nervous system and on different experimental models including cultured cells as well as living flies, worms and mice. Our understanding of synapse glia interactions in the developing, adult and diseased brain is likely to advance more rapidly as new experimental approaches to identify, visualize and manipulate glial cells in vivo become available. (C) 2009 Elsevier B.V. All rights reserved.
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