期刊
BRAIN RESEARCH REVIEWS
卷 63, 期 1-2, 页码 160-176出版社
ELSEVIER
DOI: 10.1016/j.brainresrev.2009.11.005
关键词
Gap junction; Hemichannel; Astrocyte; Oligodendrocyte; Glial network
资金
- INSERM
- Deutsche Forschungsgemeinschaft [SPP 1172 TH 1350/1-1, SFB/TR3 C9, N01]
- European Commission [FP7-202167]
This review gives an overview of connexin expression in glial cells of the central nervous system, the different modes of connexin action, including gap junctional channels and hemichannels, as well as the available methodologies to measure their activity. We summarize the strengths and limitations of current pharmacological and genetic approaches to interfere with connexin channel functions. We outline new avenues not only to study specific mechanisms by which connexins exert these functions but also to selectively investigate well-defined coupling compartments among glial networks. (C) 2009 Elsevier B.V. All rights reserved.
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