期刊
BRAIN RESEARCH REVIEWS
卷 61, 期 2, 页码 210-220出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainresrev.2009.06.004
关键词
Vasopressin; Oxytocin; HPA axis; Stress; Hippocampus; Polydipsia; Hyponatremia; Schizophrenia; Animal model
资金
- Brain Research Foundation, an affiliate of the University of Chicago
- State of Illinois funding of the Psychiatric Institute
- NIH [RO1 MH56525, 1R21MH082295, M01 RR00055, M01-RR-13987]
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR013987, M01RR000055] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH056525, R21MH082295, R29MH043618] Funding Source: NIH RePORTER
Impaired water excretion was noted to coincide with psychotic exacerbations in the first decades of the past century. in the ensuing decades, life-threatening water intoxication and elevated plasma levels of the antidiuretic hormone, arginine vasopressin (AVP) were reported in a subset of persons with schizophrenia. Subsequent studies demonstrated that the osmotic set point for AVP secretion was transiently reset in these patients by an unknown process and that this was further exacerbated by acute psychosis. more recent studies indicate that the AVP dysfunction is a manifestation of a hippocampal-mediated impairment in the regulation of both AVP and HPA axis responses to psychological, but not other types of, stimuli. of potential significance, is that schizophrenic patients without water imbalance exhibit the opposite pattern of responses. Preliminary data indicate those with water imbalance also demonstrate a closely linked deficit in central oxytocin activity which may account for their diminished social function. These latter behavioral deficits are perhaps the most disabling and treatment resistant features of schizophrenia, which recent studies suggest, may respond to oxytocin agonists. Together these findings support the view that schizophrenia is a heterogeneous disorder, and provide novel biomarkers and approaches for exploring the pathophysiology and treatment of severe mental illness. (C) 2009 Elsevier B.V. All rights reserved.
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