期刊
BRAIN RESEARCH REVIEWS
卷 57, 期 2, 页码 321-331出版社
ELSEVIER
DOI: 10.1016/j.brainresrev.2007.08.008
关键词
sexual orientation; testicular feminization; androgen insensitivity syndrome; olfactory system; sexual differentiation; androgen receptor
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH057759] Funding Source: NIH RePORTER
- NIMH NIH HHS [R01 MH057759-06, R01 MH057759, R01 MH057759-07] Funding Source: Medline
Olfactory signals play a central role in the identification of a mating partner in rodents, and the behavioral response to these cues varies markedly between the sexes. As several other sexually dimorphic traits, this response is thought to differentiate as a result of exposure of the developing individual to gonadal steroids, but both the identity of the specific steroid signal and the neural structures targeted for differentiation on this particular case are largely unknown. The present review summarizes results obtained in our lab using genetic males affected by the testicular feminization syndrome (Tfm) as experimental model, and that led to the identification of a role for non-aromatized gonadal steroids acting through the androgen receptor (AR) in the differentiation of olfactory cues processing in mice. The existing literature about AR-mediated sexual differentiation of the CNS in animal models is discussed, along with potential targets for the action of non-aromatized gonadal steroids in either one of the subsystems that detect and process olfactory information in rodents. (c) 2007 Elsevier B.V. All rights reserved.
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