期刊
BRAIN RESEARCH BULLETIN
卷 105, 期 -, 页码 17-24出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2014.04.011
关键词
CREB; Memory; Consolidation; Reconsolidation; Extinction; Memory enhancement
资金
- Core Research for Evolutional Science and Technology (CREST), Japan [23300120, 20380078, 18022038, 22022039, 24116008, 23115716]
- Sumitomo Foundation, Japan
- Takeda Science Foundation, Japan
- Grants-in-Aid for Scientific Research [24116008, 23300120, 20380078] Funding Source: KAKEN
cAMP response element-binding (CREB) has been known to be an essential transcription factor that activates gene expression required for the formation of long-term memory (LTM) in a wide range of animal models, from nematodes to higher animals such as Aplysia, Drosophila, and rodents. In mammals, various CREB mutant mice have been developed and analyzed. These studies have shown that gain or loss of CREB function improves and impairs, respectively, the formation of LTMs, enabling us to understand the roles of CREB in the formation and enhancement of memory. In this article, the analyses conducted on CREB mutant mice are reviewed with a particular focus on learning and memory formation. This article is part of a Special Issue entitled 'Memory enhancement'. (C) 2014 Elsevier Inc. All rights reserved.
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