期刊
BRAIN RESEARCH BULLETIN
卷 87, 期 2-3, 页码 193-198出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2011.11.002
关键词
Stroke; EGb761; Diffuse weighing imaging; Akt-CREB-BDNF pathway
资金
- National Natural Science Foundation [30873458]
- Beijing Municipal Natural Science Foundation [7082050]
- Top National 100 Excellent Doctoral Dissertation Special Fund [2007B7]
- Higher Education Doctoral Disciplines Points Special Research Foundation [200800271014]
EGb761 is a standard extract of Ginkgo biloba, which is a kind of traditional Chinese herbs that has widely used in clinic treatment of stroke in China. However, its effects against ischemic stroke have not been evaluated comprehensively and its neuroprotective mechanism has not really been explored. In the present study, magnetic resonance diffusion-weighted imaging (DWI), neurological behavior and TTC staining were used to evaluate the therapeutic effect of EGb761 in rat ischemic models. Additionally, Western blot and immunohistochemistry were performed to measure the phosphorylations of cAMP response element binding protein (CREB) and Akt as well as the expression of brain-derived neurotrophic factor (BDNF) in rat brains. The results showed that Ginkgo biloba extract injection significantly increased the apparent diffusion coefficient (ADC) value and average diffusion coefficient (DCavg) value both in the peripheral zone and central zone, improved behavior scores, as well as enhanced the phosphorylations of AKT, CREB and the expression of BDNF in the brains. All these data demonstrate that EGb761 had significant therapeutic effects on ischemic stroke and it perhaps worked through activating the Akt-CREB-BDNF pathway. (C) 2011 Elsevier Inc. All rights reserved.
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