期刊
BRAIN RESEARCH BULLETIN
卷 81, 期 2-3, 页码 349-358出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2009.04.004
关键词
Glaucoma; Animal models; Rodent models; Myocilin; Retina; Retinal ganglion cells; Intraocular pressure
资金
- Intramural Research Program of the National Eye Institute, National Institutes of Health
- National Institutes of Health Graduate Partnerships Program Fellowship
- Gates-Cambridge Scholarship
Glaucoma is a progressive, age-related optic neuropathy and a leading cause of irreversible blindness in the world. Animal models of glaucoma are essential to our continued efforts of elucidating the natural course of the disease and to developing therapeutic interventions to halt or reverse the progression of the condition. Over the past 10-15 years, rodents have become a popular model organism to study glaucoma, because of their high degree of availability, relatively low cost, short life-span, and amenability to experimental and genetic manipulation. In this review, we examine the numerous in vivo and in vitro rodent models of glaucoma, discuss the methods used to generate them, summarize some of the major findings obtained in these models, and identify individual strengths and weaknesses for the various systems. Published by Elsevier Inc.
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