期刊
BRAIN RESEARCH BULLETIN
卷 83, 期 3-4, 页码 103-107出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2009.08.018
关键词
Nucleosome; Core histone; Prefrontal cortex; Psychosis; Development; Lysine methylation; CpG methylation; Transcriptional repression
资金
- National Institutes of Health
- Staglin Family Music Festival Schizophrenia Research Award/NARSAD
Dysfunction of cerebral cortex and other brain regions in schizophrenia is often accompanied by dysregulated expression of numerous genes However, the underlying genetic risk architecture remains unclear for a large majority of cases Therefore, the study of epigenetic regulators of gene expression, Including covalent modifications of DNA and nucleosome core histones, offers an attractive alternative to further explore the molecular pathology of schizophrenia beyond the level of RNA quantification. Several studies reported alterations in DNA cytosine methylation and histone methylation at specific genes and promoters in postmortem brain of subjects with schizophrenia, often in conjunction with changes in levels of the corresponding RNAs. While evidence for such epigenetic dysregulation is increasing, many of the reported alterations await independent replication Interestingly, studies across the lifespan indicate that DNA and histone methylation markings are developmentally regulated in human cerebral cortex, suggesting that at least some of the epigenetic changes in the brain of adult subjects with schizophrenia reflect disordered neurodevelopment. (C) 2009 Elsevier Inc All rights reserved.
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