期刊
BRAIN RESEARCH BULLETIN
卷 78, 期 4-5, 页码 254-260出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2008.12.003
关键词
Kisspeptin; GPR54; Doral root ganglion; Spinal cord; Arthritis; Pain
资金
- National Natural Science Foundation [30500678, 30800332]
- National Key Basic Research Program of China [2007CB512502]
- Program for New Century Excellent Talents in University [NCET-04-0358]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) [IRT0522]
Kisspeptin/GPR54 system plays a crucial role in the control of puberty onset and reproductive function. In the present study, we gave the first report that kisspeptin and GPR54 were expressed in the small-to large-sized neurons, and co-localized with Bandeiraea simplicifolia isolectin B4 (IB4), calcitonin-gene-related peptide (CGRP) and neurofilament 200 (NF200) in the L4/5 dorsal root ganglion (DRG) of naive rats, detected by the double immunofluorescent staining. interestingly, a marked elevation in the levels of KiSS-1 and GPR54 mRNA as well as protein was observed in the spinal dorsal horn and DRG 4 and 14 days following intra-articular injection of complete Freund's adjuvant (CIA), indicating a possible involvement of the kisspeptin/GPR54 system in chronic inflammatory pain. (C) 2008 Elsevier Inc. All rights reserved.
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