期刊
BRAIN RESEARCH BULLETIN
卷 80, 期 6, 页码 433-442出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2009.07.016
关键词
Kv channel; Hippocampus; Immunohistochemistry; Epilepsy; Gerbil
资金
- Ministry for Health, Welfare and Family Affairs, Republic of Korea [A084589]
In order to confirm the species-specific distribution of voltage-gated K+ (Kv) channels and the definitive relationship between their immunoreactivities and seizure activity, we investigated Kv2.x Kv3.x and Kv4.x channel immunoreactivities in the hippocampi of seizure-resistant (SR) and seizure-sensitive (SS) gerbils. There was no difference in Kv2.1, Kv3.4, Kv4.2 and Kv4.3 immunoreactivity in the hippocampus between SR and SS gerbils. In comparison to SR gerbils, Kv3.1b immunoreactivity in neurons was significantly lower in SS gerbils instead Kv3.1b-immunoreactive astrocytes were clearly observed in SS gerbils (p < 0.05). Kv3.2 immunoreactivity was also significantly lower in neurons of SS gerbils than in those of SR gerbils (p < 0.05). Considering the findings of our previous study, these findings suggest that delayed rectifier K+ channels (Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv2.1 and Kv3.1-2), not A-type K+ channels (Kv1.4, Kv3.4 and Kv4.x), may be down-regulated in the SS gerbil hippocampus, as compared to SR gerbils. (C) 2009 Elsevier Inc. All rights reserved.
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