期刊
BRAIN RESEARCH
卷 1584, 期 -, 页码 116-128出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2014.04.005
关键词
Antisense oligonucleotides; Delivery; RNA interference; siRNA; microRNA; Neurodegeneration
Molecular genetics insight into the pathogenesis of several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis, encourages direct interference with the activity of neurotoxic genes or the molecular activation of neuroprotective pathways. Oligonucleotide-based therapies are recently emerging as an efficient strategy for drug development and these can be employed as new treatments of neurodegenerative states. Here we review advances in this field in recent years which suggest an encouraging assessment that oligonucleotide technologies for targeting of RNAs will enable the development of new therapies and will contribute to preservation of brain integrity. This article is part of a Special Issue entitled RNA Metabolism 2013. (C) 2014 Elsevier B.V. All rights reserved.
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