期刊
BRAIN RESEARCH
卷 1589, 期 -, 页码 93-104出版社
ELSEVIER
DOI: 10.1016/j.brainres.2014.09.033
关键词
Parkinson's disease; 6-hydroxydopamine; Neuroprotection; 6-(methylsulfinyl)hexyl isothiocyanate; Oxidative stress
资金
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR)
- FIRB-Accordi di programma [RBAP11HSZS]
- Fondazione Cassa di Risparmio di Imola
- [2010PWNJXK_002]
A number of pathogenic factors have been implicated in the progression of Parkinson's disease (PD), including oxidative stress, mitochondrial dysfunction, inflammation, excitotoxicity, and signals mediating apoptosis cascade. 6-(methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major component in wasabi, a very popular spice in Japan and a member of the Brassica family of vegetables. This study was designed to investigate the neuroprotective effects of 6-MSITC in a PD mouse model. Mice were treated with 6-MSITC (5 mg/kg twice a week) for four weeks after the unilateral intrastriatal injection of 6-hydroxydopamine (6-OHDA). On the 28th day, 6-OHDA-injected mice showed behavioral impairments, a significant decrease in tyrosine hydroxylase (TH) and an increase in apoptosis. In addition, lesioned mice showed reduced glutathione levels and glutathione-S-transferase and glutathione reductase activities. Notably, 6-MSITC demonstrated neuroprotective effects in our experimental model strongly related to the preservation of functional nigral dopaminergic neurons, which contributed to the reduction of motor dysfunction induced by 6-OHDA. Furthermore, this study provides evidence that the beneficial effects of 6-MSITC could be attributed to the decrease of apoptotic cell death and to the activation of glutathione-dependent antioxidant systems. These findings may render 6-MSITC as a promising molecule for further pharmacological studies on the investigation for disease-modifying treatment in PD. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据