期刊
BRAIN RESEARCH
卷 1515, 期 -, 页码 19-28出版社
ELSEVIER
DOI: 10.1016/j.brainres.2013.03.048
关键词
Rat; Early-life-permethrin-treatment; Brain; Nurr1; NF-kB; Nrf-2
资金
- MIUR, National Grant [2008ZW3FJ3]
Pesticide exposure during brain development represents an important risk factor for the onset of brain-aging processes. Here, the impact of permethrin administered to rats from 6th to 21st day of life, at a dose near to no observed adverse effect level (NOAEL), was studied when animals reached 500 day-old. The permethrin treatment induced a decrease in Nurr1 gene expression in striatum, an increase in hippocampus and cerebellum, while the protein level changed only in striatum where it was increased. NF-kB p65 gene expression was increased in cerebellum, while its protein level augmented in cerebellum and in prefrontal cortex and decreased in hippocampus of treated rats compared to control ones. Nrf-2 gene expression resulted significantly higher only in cerebellum of treated animals. The results suggest that early life permethrin treatment induces long-lasting effects leading to dopaminergic neuronal disorders, monitored by Nurr1 alteration. Moreover the impairment of NF-kB and Nrf-2, important for the balance between pro- and antiinflammatory systems, confirms that the neonatal permethrin treatment can influence genes involved with the onset of brain-ageing processes. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据