期刊
BRAIN RESEARCH
卷 1530, 期 -, 页码 13-21出版社
ELSEVIER
DOI: 10.1016/j.brainres.2013.07.043
关键词
Neurite outgrowth; L1; FGF21; FGFR
资金
- National Natural Science Foundation of China [31070728]
- Liaoning Province education bureau [L2010103]
- Talent Program of Yunnan Province, China
- Monash University
L1 plays a role in neural development. However, it remains unclear how L1 plays this role. In the present study, we have shown extensive outgrowth of long neurites in cerebellar neurons after treatment with either L1 or L1 antibody. Notably, the mRNA level of FGF21 was significantly increased in both L1. and L1 antibody treated neurons compared to control group. Consistently, the neurite outgrowth promoted by L1 was strongly inhibited by siRNA against FGF21 gene or a treatment of cells with FGFR inhibitor. These results demonstrate that FGF21/FGFR signaling promotes the neurite outgrowth in a L1-dependent manner. (C) 2013 Elsevier B.V. All rights reserved.
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