期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 446, 期 -, 页码 290-297出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2015.01.048
关键词
3D network; Enhanced mixing; Microfluidic technology; Cancer serum
资金
- NSF of China [51172042]
- MOST of China [2012AA030309]
- MOE of China [IRT1221, 111-2-04]
- STC of Shanghai [12nm0503900, 13JC1400200]
- SRFDP [20110075130001]
- Donghua University [CUSF-DH-D-2013002]
- Chinese Scholarship Council
Glass/silica-based flow channels are widely used in capillary electrophoresis and micro-total analysis systems. However, it is almost impossible to achieve controllable fabrication of microstructures with enhanced mixing performance for high-efficiency bio-analysis in confined micro-channels. Here, various morphologies were controllably achieved by tuning the molar ratio of the reaction agents in a confined microchannel. Fluid flow simulation is demonstrated to investigate the structure stability and mixing performance. Multifunctional networks with uniform and deep decoration are fabricated in confined micro-capillaries, owing to the enhanced mixing performance. The modified micro-capillaries exhibit high efficiencies for the selective enrichment of phosphopeptides from traditional model samples. Furthermore, the fabricated micro-capillaries also exhibited high performance in practical applications (for selective enrichments from bovine milk and cancer serum). These outstanding features make the microstructure-modified micro-capillaries promising for bio-analysis. (C) 2015 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据