期刊
BRAIN RESEARCH
卷 1469, 期 -, 页码 103-113出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2012.05.058
关键词
Epilepsy; Aspirin; Inflammation; Epileptogenesis; Mossy fiber sprouting; Neurogenesis
资金
- Natural Science Foundation of China [30870840, 81071051]
- Program for New Century Excellent Talents in University [NCET-07-0146]
Accumulating data suggest that inflammation may contribute to epileptogenesis in experimental models as well as in humans. However, whether anti-inflammatory treatments can prevent epileptogenesis still remains controversial. Here, we examined the anti-epileptogenic effect and possible mechanisms of aspirin, a non-selective Cyclooxygenase (COX) inhibitor, in a rat model of lithium-pilocarpine-induced status epilepticus (SE). Epileptic rats were treated with aspirin (20 mg/kg) at 0 h, 3 h, or 24 h after the termination of SE, followed by once daily treatment for the subsequent 20 days. We found that aspirin treatment significantly reduced the frequency and duration of spontaneous recurrent seizures during the chronic epileptic phase. Hippocampal neuronal loss five weeks after SE was also attenuated in the CA1, CA3 and hilus following aspirin administration. Furthermore, the aberrant migration of newly generated granule cells and the formation of hilar basal dendrites were prevented by aspirin. Treatment with aspirin starting at 3 h or 24 h after SE also suppressed the development of mossy fiber sprouting. These findings suggest the possibility of a relative broad time-window for aspirin intervention in the epileptogenic process after injury. Aspirin may serve as a potential adjunctive therapy for individuals susceptible to chronic epilepsy. (C) 2012 Elsevier B.V. All rights reserved.
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