期刊
BRAIN RESEARCH
卷 1461, 期 -, 页码 1-9出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2012.04.037
关键词
Hippocampus; Sharp wave; Ripple; Muscarinic receptor; Calcium imaging; Acetylcholine
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18021008, 22115003, 22115013, 22650080, 22680025]
- Suzuken Memorial Foundation
- Kanae Foundation for the Promotion of Medical Science
- Daiichi-Sankyo Foundation of Life Science
- Funding Program for Next Generation World-Leading Researchers [LS023]
- Grants-in-Aid for Scientific Research [18021008, 22650080, 22390012, 22115013, 10J10704, 22680025] Funding Source: KAKEN
Cholinergic muscarinic innervations to the hippocampus play a role in learning and memory. Here we report that pharmacological activation of muscarinic receptors eliminates sharp wave-ripple events in the mouse hippocampal CA1 region in vivo and in vitro. This effect was associated with a decorrelation of excitatory synaptic inputs and a net increase in inhibitory conductances in pyramidal neurons. Multineuron calcium imaging revealed that muscarinic activation altered the spatiotemporal pattern of network activities. Thus, cholinergic input is likely to contribute to a neuromodulatory switch of hippocampal network states, as proposed in the two-stage model of learning processes. (C) 2012 Elsevier B.V. All rights reserved.
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