期刊
BRAIN RESEARCH
卷 1439, 期 -, 页码 15-26出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2011.12.043
关键词
Nomifensine; 4-Phenyl-1,2,3,4-tetrahydroisoquinoline; Methamphetamine; Persistent locomotion; Stereotypical behavior
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [21790254]
- National Institute on Drug Abuse (USA, GRU and FSH)
- Grants-in-Aid for Scientific Research [21790254] Funding Source: KAKEN
Nomifensine is a dopamine/norepinephrine reuptake inhibitor. Nomifensine and some of its structural analogues produce behavioral effects indicative of indirect dopaminergic agonist properties, such as hyperlocomotion. By contrast, the deaminated and demethylated nomifensine analogue 4-phenyl-1,2,3,4-tetrahydroisoquinoline (PTIQ) is reported to have amphetamine-antagonistic properties, as demonstrated by inhibition of methamphetamine (METH)-induced dopamine release in the nucleus accumbens and METH-induced hyperlocomotion in rats. In the present study, we examined the effect of PTIQ (10 mg/kg, i.p.) and nomifensine (3 mg/kg, i.p.) on METH (5 or 10 mg/kg, i.p.)-induced stereotypical behavior in mice in order to determine whether PTIQ and nomifensine inhibit and augment, respectively, METH-induced stereotypical behavior. Unexpectedly, our observations demonstrated that both PTIQ and nomifensine significantly augmented METH-induced stereotypical behavior and locomotion in mice. This augmentation is likely the result of additive effects on dopaminergic function by METH in combination with PTIQ or nomifensine. These results suggest that, contrary to some reports, PTIQ may display dopaminergic agonist properties in mice. (C) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据