期刊
BRAIN RESEARCH
卷 1380, 期 -, 页码 206-217出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2010.08.067
关键词
Autism; Frontoinsular cortex; Neuropathology; Stereology; von Economo neurons
资金
- Vachoux Foundation
- Autism Speaks
- James S. McDonnell Foundation
- Simons Foundation
The presence of von Economo neurons (VENs) in the frontoinsular cortex (FI) has been linked to a possible role in the integration of bodily feelings, emotional regulation, and goal-directed behaviors. They have also been implicated in fast intuitive evaluation of complex social situations. Several studies reported a decreased number of VENs in neuropsychiatric diseases in which the embodied dimension of social cognition is markedly affected. Neuropathological analyses of VENs in patients with autism are few and did not report alterations in VEN numbers. In this study we re-evaluated the possible presence of changes in VEN numbers and their relationship with the diagnosis of autism. Using a stereologic approach we quantified VENs and pyramidal neurons in layer V of FI in postmortem brains of four young patients with autism and three comparably aged controls. We also investigated possible autism-related differences in FI layer V volume. Patients with autism consistently had a significantly higher ratio of VENs to pyramidal neurons (p=0.020) than control subjects. This result may reflect the presence of neuronal overgrowth in young patients with autism and may also be related to alterations in migration, cortical lamination, and apoptosis. Higher numbers of VENs in the FI of patients with autism may also underlie a heightened interoception, described in some clinical observations. (C) 2010 Elsevier B.V. All rights reserved.
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