期刊
BRAIN RESEARCH
卷 1380, 期 -, 页码 198-205出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2010.12.057
关键词
Autism; Spectroscopy; Glutamate; Anterior cingulate cortex; Temporoparietal junction; Myo-inositol
资金
- National Center for Research Resources [M01 RR000071]
- NARSAD
- NIMH [MH083164]
Attentional dysfunction is one of the most consistent findings in individuals with autism spectrum disorders (ASD). However, the significance of such findings for the pathophysiology of autism is unclear. In this study, we investigated cellular neurochemistry with proton magnetic resonance spectroscopy imaging (H-1-MRS) in brain regions associated with networks subserving alerting, orienting, and executive control of attention in patients with ASD. Concentrations of cerebral N-acetyl-aspartate (NAA), creatinine + phosphocreatinine, choline-containing compounds, myo-inositol (Ins) and glutamate + glutamine (Glx) were determined by 3 T H-1-MRS examinations in 14 high-functioning medication-free adults with a diagnosis of ASD and 14 age- and IQ-matched healthy controls (HC) in the anterior cingulate cortex (ACC), thalamus, temporoparietal junction (TPJ), and areas near or along the intraparietal sulcus (IFS). Compared to HC group, the ASD group showed significantly lower Glx concentration in right ACC and reduced Ins concentration in left TPJ. This study provides evidence of abnormalities in neurotransmission related to networks subserving executive control and alerting of attention, functions which have been previously implicated in ASD pathogenesis. (C) 2010 Elsevier B.V. All rights reserved.
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