期刊
BRAIN RESEARCH
卷 1404, 期 -, 页码 63-71出版社
ELSEVIER
DOI: 10.1016/j.brainres.2011.06.024
关键词
Oxidative stress; Anxiety; Antioxidants; Hypertension; Inflammation
资金
- GEAR
- UH
- SURF
- PURS
- NIH/NIAAG [29904]
- Academy of Finland
Previously, we have published that pharmacological induction of oxidative stress causes anxiety-like behavior in rats and also is associated with hypertension in these animals. Here, we report that sub-chronic induction of oxidative stress via pharmacological induction leads to i) reduction in glyoxalase (GLO)-1 and glutathione reductase (GSR)-1 expression; ii) calpain mediated reduction of brain derived neurotrophic factor (BDNF) levels; iii) NF kappa B mediated upregulation of proinflammatory factors interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha and elevated angiotensin (AT)-1 receptor levels in hippocampus, amygdala and locus coeruleus regions of the brain. Acute oxidative stress has opposite effects. We speculate that regulation of GLO1, GSR1, BDNF, NF kappa B and AT-1 receptor may contribute to anxiety-like behavior and hypertension in rats. Published by Elsevier B.V.
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