期刊
BRAIN RESEARCH
卷 1375, 期 -, 页码 111-119出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2010.12.042
关键词
Cocaine; Functional magnetic resonance; imaging; Parietal cortex; Attention; Working memory; Behavioral performance
资金
- FEPAD (Fundacion para el Estudio, Prevencion y Asistencias a la Drogodependencia)
- National Plan of Drugs (Plan Nacional de Drogas)
- BRAINGLOT, a Spanish Research Network on Bilingualism and Cognitive Neuroscience, Spanish Ministry of Science and Education [CSD2007-00012]
- Universitat Jaume I of Castellon [PREDOC/2007/13]
It has been suggested that cocaine addiction affects the engagement of the frontoparietal networks in executive functions, such as attention and working memory. Thus, our objective was to investigate brain differences between cocaine-dependent subjects and healthy controls during the performance of a verbal working memory task. Nineteen comparison men and nineteen cocaine-dependent men performed a 2-back task. Data were acquired on a 1.5-T Siemens Avanto. Image processing and statistical analyses were carried out using SPM5; Biological Parametric Mapping (BPM) was used for further morphometric and correlation analyses. No performance differences were found between groups. However, the dorsal part of the right inferior parietal cortex (BA 40) was less activated in the cocaine-dependent group. Cocaine patients did not overactive any brain area when compared with controls. Our results show reduced activation in the brain areas related to the attention system in cocaine-dependent men while performing a verbal working memory task. Chronic cocaine use may affect the attentional system in the right parietal lobe, making patients more prone to attentional deficits. (C) 2010 Elsevier B.V. All rights reserved.
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