期刊
BRAIN RESEARCH
卷 1382, 期 -, 页码 238-244出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2010.12.079
关键词
Retinitis pigmentosa; Olfactory nerve fibroblasts; Migration; Gliosis; Neuroprotection; Retinal degeneration disease
资金
- Nature Science Foundation of China [30910103913]
- National Basic Research Program of China [2007CB512203]
Retinitis pigmentosa leads to progressive visual loss and blindness. Until now there has been no effective therapy. Experimental studies have shown that transplantation of olfactory ensheathing cells into CNS lesions reorganizes the glial scar and stimulates axon regeneration. We now report that cultured syngeneic adult rat olfactory ensheathing cells transplanted into the subretinal space of pigmented Royal College of Surgeon rats survived for a minimum of 8 weeks, migrated into surrounding space, and suppressed the gliotic injury response of the Muller cells. Further investigation of intraretinal transplantation of olfactory ensheathing cells may suggest a possible future route for protection of the retina in retinitis pigmentosa. (C) 2011 Elsevier B.V. All rights reserved.
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