期刊
BRAIN RESEARCH
卷 1377, 期 -, 页码 21-31出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2010.12.073
关键词
Electroencephalography (EEG); Mutual information; Power spectrum; Catechol-O-methyl-transferase (COMT); Polymorphism
资金
- Department of Health, Taiwan, ROC [DOH94-NNB-1035]
- Kai-Suan Psychiatric Hospital-Kaohsiung [KS92-015]
The catechol-O-methyl-transferase (COMT) gene has been linked to a wide spectrum of human phenotypes, including cognition, affective response, pain sensitivity, anxiety and psychosis. This study examined the modulatory effects of COMT Val158Met on neural interactions, indicated by connectivity strengths. Blood samples and resting state eyes-closed EEG signals were collected in 254 healthy young females. The COMT Val158Met polymorphism was decoded into 3 groups: Val/Val, Val/Met and Met/Met. The values of mutual information of 20 frontal-related channel pairs across delta, theta, alpha and beta frequencies were analyzed based on the time-frequency mutual information method. Our one-way ANOVA analyses revealed that the significant connection-frequency pairs were relatively left lateralized (P<0.01) and included F7-T3 and F7-C3 at delta frequency, and F3-F4, F7-T3, F7-C3, F7-P3, F3-C3, F3-F7 and F4-F8 at theta frequency. The F-test at F7-T3 and F7-C3 theta surpassed the statistical threshold of P<0.003 (after Bonferroni correction). For all the above connection-frequency pairs, there was a dose-dependent trend in the connectivity strengths of the alleles as follows: VaVVal>VaVMet>Met/Met. Our analyses complemented previous literature regarding neural modulation by the COMT Val158Met polymorphism. The implication to the pathogenesis in schizophrenia was also discussed. Further studies are needed to clarify whether there is gender difference on this gene-brain interaction. (C) 2010 Elsevier B.V. All rights reserved.
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