期刊
BRAIN RESEARCH
卷 1381, 期 -, 页码 217-227出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2011.01.009
关键词
Embolic stroke; MRI; Brain ischemia; Brain imaging; Animal model
资金
- NIH [RO1 NS48349, P50 NS23393, PO1 NS42345]
- Yerkes National Primate Center [P51 RR000165]
We offer a new means of noninvasively assessing mean microvessel segment length and radius after ischemic stroke. This method involves measuring changes in T-2 and T*(2) after injecting an intravascular superparamagnetic iron oxide contrast agent and result was verified using laser scanning confocal microscopy (LSCM) of both normal brain tissue and the ischemic recovery region. Embolic stroke was induced in 8 male Wistar rats and magnetic resonance imaging (MRI) performed 1 day and 6 weeks later. On MRI taken at 6 weeks, MRI of the recovery region revealed a significant increase in mean vessel size index (VSI) (5.75 +/- 0.54 vs 4.81 +/- 0.39 mu m; p<0.001) and decrease in mean segment length (MSL) (16.61 +/- 2.33 vs 26.521 +/- 3.20) mu m; p<0.001) compared to the normal contralateral hemisphere, comparable with published values. There was also a significant correlation between MSL and VSI measured by MRI vs LSCM in the recovery region and normal contralateral hemisphere (p<0.001). Our data suggest that a) morphological changes in the microvasculature can be measured noninvasively using MRI, and b) both MRI and LSCM give comparable information about both of these important parameters. (C) 2011 Elsevier B.V. All rights reserved.
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