期刊
BRAIN RESEARCH
卷 1388, 期 -, 页码 22-31出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2011.03.004
关键词
Vesicular glutamate transporter 1 (VGluT1); Vesicular GABA transporter (VGAT); Postnatal development; Human; Schizophrenia
资金
- National Health and Medical Research Council of Australia Schizophrenia Research Institute
- National Institute of Alcohol Abuse and Alcoholism (NIH (NIAAA) [R24AA012725]
A balance between excitatory and inhibitory neurotransmission is important in normal brain function, and in schizophrenia a deficit in gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission has been indicated by postmortem studies. We examined the ratio of excitatory to inhibitory vesicular neurotransmitter transporter mRNAs (VGluT1 to VGAT) and their ratio in the dorsolateral prefrontal cortex during normal human development and in people with schizophrenia and controls by quantitative RT-PCR. The ratio of VGluT1/VGAT increased gradually in development to reach a peak at school age (5-12 years), after which levels remained fairly constant into adulthood. The VGluT1 mRNA/VGAT mRNA ratio was unchanged in schizophrenia, as was the ratio of complexin 2 mRNA to complexin 1 mRNA (related to synaptic vesicle fusion in excitatory and inhibitory terminals, respectively). This suggests that the excitatory/inhibitory balance is attained prior to adolescence and is maintained across the rest of the life-span and also indicates that in schizophrenia this balance is not greatly disturbed. (C) 2011 Elsevier B.V. All rights reserved.
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