期刊
BRAIN RESEARCH
卷 1307, 期 -, 页码 53-62出版社
ELSEVIER
DOI: 10.1016/j.brainres.2009.10.039
关键词
Inner ear hair cell; Stereocilia; Protein 4.1G; Protein 4.1B; MyosinXV-whirlin complex
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [17680034]
- Japan Society for the Promotion of Science [20300147]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- MRC and EUROHEAR [LSHG-CT-2004-512063]
- Grants-in-Aid for Scientific Research [20300147] Funding Source: KAKEN
- MRC [MC_U142684172, MC_U142684175] Funding Source: UKRI
- Medical Research Council [MC_U142684175, MC_U142684172] Funding Source: researchfish
Protein 4.1 (band 4.1 or 4.1R) was originally identified as an abundant protein of the human erythrocyte, in which it stabilizes the spectrin/actin cytoskeleton. Subsequently, several new family members, 4.1N, 4.1G and 4.1B, have been identified, which are expressed in many cell types, in particular at cell-cell junctions. We previously reported that 4.1R and 4.1N are expressed in the inner ear hair cells with specific localization patterns, and that 4.1R forms a complex with the membrane-associated guanylate kinase (MAGUK) protein p55 and two deafness gene products, myosin XV and whirlin. To determine the functions of the other family members, 4.1G and 4.1B, we observed their expression patterns in developing stereocilia in mice inner ear hair cells. 4.1G is expressed in the basal tapers of the stereocilia bundle in early postnatal stages. 4.1B was specifically and constantly expressed in the stereocilia tips during postnatal development. Additionally, we found that 4.1B is ablated in the hair cells of both myosin XV and whirlin mutant mice at all stages in hair cell development. These results suggest that 4.1 family members play important roles in the development and maintenance of the inner ear hair cells, and that 4.1B may be a member of the myosin XV-whirlin complex that is important for stereocilia maturation. (C) 2009 Elsevior B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据