期刊
BRAIN RESEARCH
卷 1315, 期 -, 页码 159-168出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2009.12.014
关键词
Corticosterone; GR; Vulnerability; LPS; Neuroinflammation
资金
- Spanish Ministry of Education (MEC) [SAF07-63138]
- Instituto de Salud Carlos III
- Centro de Investigacion en Red de Salud Mental
- CIBERSAM
- Foundation Santander UCM [GR 58/08]
- FPU fellowship (MEC)
To assess whether the individual differences on the brain response to lipopolysaccharide (LPS) are correlated with the individual differences in the hypothalamus-pituitary-adrenal axis basal activity, adult male outbred rats were injected i.p. with 1 mg/kg LPS and evaluated after 4 h. Basal (1 week before LPS) and post-LPS plasma corticosterone (CC) were measured (mean basal: 225 +/- 22 ng/mL at 15:00 h). Group H was assigned to animals with 33% higher levels of CC (> 234 ng/mL) and group L to animals with 33% lower levels of CC (< 167 ng/mL). The H group showed an 8.8 times less relative increase of CC after LPS than the L group as well as a reduced glucocorticoid receptor upregulation after LPS. In addition, H individuals present higher plasma levels of TNF-alpha and IL-1 beta after LPS. interestingly, these animals are more vulnerable to the accumulation of oxidative/nitrosative mediators in the brain (NF-kappa B, NOS-2 and COX-2). Concomitantly, H animals are less protected against LPS-induced neuroinflammation, since anti-inflammatory mediators, lipocalin-prostaglandinD2 synthase and peroxisome proliferator-activated gamma, are downregulated after LPS. These data demonstrate that CC plasma basal levels might be a relevant parameter for predicting the individual response to LPS. (C) 2009 Elsevier B.V. All rights reserved.
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