期刊
BRAIN RESEARCH
卷 1353, 期 -, 页码 225-233出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2010.07.023
关键词
Unpredictable chronic mild stress; Depression; Hot plate test; Neuropathic pain; Von Frey filament; Allodynia
资金
- NNSF [30700223, 30770688, 30970959]
- Beijing NNSF [5082008]
- Chinese Academy of Sciences
- National Hi-Tech Research and Development Program of China [2008AA022604]
- NIH Fogarty International Center [R03TW008038]
Clinical observations suggest that depressed patients were less sensitive to experimental pain than healthy subjects. However, few animal studies are reported concerning the association of depression and pain. The purpose of this study was to investigate the effects of unpredictable chronic mild stress (UCMS) induced depression on the perceived intensity of painful stimulation in rats. We measured the thermal and mechanical paw withdrawal thresholds (PWT) of normal and spinal nerve ligated (SNL) rats using hot plate test and von Frey test, respectively. The results showed that rats exposed to UCMS exhibited significantly higher thermal and mechanical pain thresholds in comparison to the non-depressed controls. In particular, the PWT of the SNL group was restored to nearly normal level after three weeks of UCMS, and even comparable to that of the control group. These results strongly suggest that the depressed subjects have decreased sensitivity to externally applied noxious stimulation, which is consistent with our previous findings. (C) 2010 Elsevier B.V. All rights reserved.
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