期刊
BRAIN RESEARCH
卷 1251, 期 -, 页码 7-15出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2008.11.061
关键词
ADP-ribosylation factor 6; Rac1; Guanine nucleotide exchange factor; Postsynaptic density; PSD-95
资金
- Ministry of Education, Science, Sports, Culture and Technology of Japan [19300119]
- Grants-in-Aid for Scientific Research [19300119] Funding Source: KAKEN
IQ-ArfGEF/BRAG1, a guanine nucleotide exchange factor for Arf1 and Arf6, is localized at the postsynaptic density (PSD) and interacts with PSD-95. In this study, we identified a novel interaction of IQ-ArfGEF/BRAG1 with insulin receptor tyrosine kinase substrate of 53 kDa (IRSp53), also known as brain-specific angiogenesis inhibitor 1-associated protein 2. The interaction was mediated by the binding of the C-terminal proline-rich sequence of IQArfGEF/BRAG1 to the SH3 domain of IRSp53. IQ-ArfGEF/BRAG1 and IRSp53 were colocalized at the PSD of excitatory synapses of certain neuronal populations. Our present findings suggest that IQ-ArfGEF/BRAG1 may play roles downstream of NMDA receptors through the interaction with multivalent PSD proteins such as IRSp53 and PSD-95. (c) 2008 Elsevier B.V. All rights reserved.
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