期刊
BRAIN RESEARCH
卷 1287, 期 -, 页码 39-46出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2009.06.075
关键词
Lewis(x); TI-VAMP; Neurite outgrowth; GABAergic interneuron; Glutamatergic neuron; Rat hippocampus culture
资金
- European Commission [LSHG-CT-2004-503228,, 500039-2]
- Fundacao para a Ciencia e a Tecnologia, Portugal
- Association pour la Recherche sur le Cancer
The Lewis(x) (Le(x)) epitope (Gal(beta 1-4)[Fuc(alpha 1-3)]GlcNAc-R) has been associated with the development of the central nervous system of diverse species including human and rodents. In this work, Le(x) has been found in the tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) compartment of rat hippocampus neurons in culture, at 7 days in vitro (DIV), when neurite extension is abundant. The TI-VAMP compartment is known to be associated with neurite outgrowth. Le(x) was found predominantly in neurites but also in somata and in growth cones. Abundant Le(x)-carrier glycoproteins specific to neurons have been identified at this stage of differentiation. At a later stage of differentiation, at 14 DIV, Le(x) appeared in extrasynaptic sites of GABAergic neurons, and in synaptic sites of glutamatergic neurons. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据