期刊
BRAIN RESEARCH
卷 1265, 期 -, 页码 171-177出版社
ELSEVIER
DOI: 10.1016/j.brainres.2009.02.013
关键词
Diffusion tensor imaging; Voxel-based morphometry; Autistic disorder; White matter
资金
- National Natural Science Foundation of China [30S70655, 60628101]
- The Key Program of Medical Development of Nanjing [zkx06025]
- Natural Science Foundation of JiangSu [BK2008082]
- National Institutes of Health [HD51656]
This study explored white matter abnormalities in a group of Chinese children with high functioning autism (HFA). Twelve male children with HFA and ten matched typically developing children underwent diffusion tensor imaging (DTI) as well three-dimensional T1-weighted MRI for voxel-based morphometry (VBM). We found a significant decrease of the white matter density in the right frontal lobe, left parietal lobe and right anterior cingulate and a significant increase in the right frontal lobe, left parietal lobe and left cingulate gyrus in the HFA group compared with the control group. The HFA group also had decreased FA in the frontal lobe and left temporal lobe. By combining DT-MRI FA and MRI volumetric analyses based on the VBM model, the results showed consistent white matter abnormalities in a group of Chinese children with HFA. (C) 2009 Elsevier B.V. All rights reserved.
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