期刊
BRAIN RESEARCH
卷 1192, 期 -, 页码 29-36出版社
ELSEVIER
DOI: 10.1016/j.brainres.2007.05.021
关键词
interkinetic nuclear migration; nuclear translocation; nucleokinesis; neurogenesis; dynein; cell cycle; cell behavior
资金
- NEI NIH HHS [R01 EY014167, T32 EY014536, R01 EY014167-05A1, 5T32EY014536, R01EY01467, R01 EY014167-04] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007121] Funding Source: Medline
In this review we focus on the mechanisms, regulation, and cellular consequences of nuclear migration in the developing retina. In the nervous system, nuclear migration is prominent during both proliferative and post-mitotic phases of development. Interkinetic nuclear migration is the process where the nucleus oscillates from the apical to basal surfaces in proliferative neuroepithelia. Proliferative nuclear movement occurs in step with the cell cycle, with M-phase being confined to the apical surface and G1-, S-, and G2-phases occurring at more basal locations. Later, following cell cycle exit, some neuron precursors migrate by nuclear translocation. In this mode of cellular migration, nuclear movement is the driving force for motility. Following discussion of the key components and important regulators for each of these processes, we present an emerging model where interkinetic nuclear migration functions to distinguish cell fates among retinal neuroepithelia. (C) 2007 Elsevier B.V. All rights reserved.
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