期刊
PLANT SIGNALING & BEHAVIOR
卷 5, 期 7, 页码 839-841出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/psb.5.7.11820
关键词
nudix hydrolase; ADP-ribose/NADH pyrophosphohydrolases; biotic and abiotic stress response
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [19208031]
- CREST, JST
- Grants-in-Aid for Scientific Research [22248042] Funding Source: KAKEN
Among Arabidopsis Nudix hydrolases (AtNUDX1 similar to 27), AtNUDX6 and AtNUDX7 having ADP-ribose/NADH pyrophosphohydrolase activities have been found to contribute to keeping the energy and redox homeostasis, and/or modulating defense responses against biotic and abiotic stress. Interestingly, AtNUDX6 had an opposite effect to AtNUDX7 on the regulation of immune responses. A comparison of the activities of ADP-ribose/NADH pyrophosphohydrolase among wild-type, knockout (KO)-nudx6, and KO-nudx7 plants revealed AtNUDX7 to contribute more than AtNUDX6 to the total pyrophosphohydrolase activity toward both ADP-ribose and NADH under normal conditions and oxidative stress, while AtNUDX6 accounted for the majority of total NADH pyrophosphohydrolase activity under salicylic acid treatment. These results support the idea that the metabolism of ADP-ribose and/or NADH needs to be finely tuned for accurate regulation of cellular responses to biotic and abiotic stress.
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