期刊
BRAIN RESEARCH
卷 1194, 期 -, 页码 28-36出版社
ELSEVIER
DOI: 10.1016/j.brainres.2007.11.057
关键词
adolescence; alcohol; EEG; alcoholism; age; gamma
资金
- NIAAA NIH HHS [R01 AA006059, R01 AA014339, AA006059, 5T32 AA007456-24, R01 AA014339-04, T32 AA007456, R01 AA014339-03, R01 AA006059-18, R01 AA006059-17A1] Funding Source: Medline
Age-related developmental differences in sensitivity to the acute effects of alcohol may play an important role in the development of alcoholism. The present study was designed to evaluate the acute effects of alcohol on cortical electroencephalogram (EEG) in adolescent (P36) and adult (P78) Wistar rats. Five minutes of EEG was recorded after administration of 0, 0.75 or 1.5 g/kg alcohol. The righting reflex was performed to measure the sedative effects of alcohol (33 g/kg) and total sleeping time for each rat. Our results showed that alcohol (1.5 g/kg) increased power in the 1-2 Hz band and decreased the power in the 32-50 Hz band in the parietal cortical region of adolescent rats. Alcohol (1.5 g/kg) also increased stability of the EEG power in the slow-wave frequency bands (2-4 Hz, 4-6 Hz, and 6-8 Hz) of adolescent rats. In the frontal cortex of adult ran, but not in adolescent rats, alcohol (1.5 or 0.75 g/kg) decreased the power in the 16-32 Hz frequency band. Alcohol (1.5 g/kg) differentially increased power in a multiple of slow-wave frequency bands (2-4 Hz and 4-6 Hz) in the parietal cortex of adult rats as compared to adolescent rats. Adolescent rats were shown significantly shorter sleeping time and higher blood alcohol levels after regaining reflex than adult rats. Our results provide additional evidence of age-related differences in the effects of acute alcohol on cortical EEG, sedation and tolerance. (c) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据