期刊
BRAIN RESEARCH
卷 1220, 期 -, 页码 70-80出版社
ELSEVIER
DOI: 10.1016/j.brainres.2007.10.047
关键词
40 Hz; auditory cortex; ERP; local field potential; EEG; frequency modulated sound; gamma activity; oscillation
资金
- Deutsche Forschungsgemeinschaft [SFB-TR 31, A3, A9]
- European community [FP6-IST-027787]
- German Ministry of Science and Technology [BMBF BioFuture 0311891]
Tightly stimulus-locked evoked and not tightly stimulus-locked induced gamma-band oscillations have been implicated in a variety of cognitive functions as well as more basic stimulus-related aspects of neuronal activity. The present study aimed at dissociating both aspects using a preparation in rodents trained to perform in a target-discrimination task while recording the intracerebral electrocorticogram in parallel from left and right auditory cortex. While stimulus-related aspects of gamma-band activity were already evident in the naive subjects, aspects related to successful target-discrimination only emerged with learning. Frequency-modulated tones were employed as stimuli and were varied with respect to two stimulus dimensions, viz. spectral content and modulation direction. A target stimulus had to be discriminated in a GO/(NO-GO) paradigm from three non-target stimuli matching the target in only one or none of these dimensions. Analysis of the event-related potentials indicated that the physical stimulus parameters explained most of the variance in amplitude of most event-related potential components. For the evoked gamma-band activity no learning related modulations were found. The induced gamma-band activity showed a relationship with the similarity of a stimulus with the target that was most prominent in the right hemisphere. The correspondence between task-specific behavior and the amplitude of induced gamma-band activity, both developing with learning, supports a functional relevance of this form of oscillation beyond merely processing physical stimulus attributes. (C) 2007 Elsevier B.V. All rights reserved.
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