期刊
BRAIN PATHOLOGY
卷 21, 期 6, 页码 633-644出版社
WILEY
DOI: 10.1111/j.1750-3639.2011.00491.x
关键词
brain tumor; database; epidemiology; neuro-oncology; neuropathology; neurosurgery
资金
- Ligue Nationale Contre le Cancer (France)
- INCa
- Schering-Plough Laboratory
- Roche Laboratory
- ANOCEF
- SFNC
- Associations pour la Recherche sur les Tumeurs Cerebrales (ARTC and ARTC Sud) (France)
- Departement de l'Herault (France)
- Rotary Club (AGLY)
- Archimedes Pharma Laboratory, Sophysa Laboratory
- Groupe de Neuro-Oncologie du Languedoc Roussillon (France)
This work aimed to prospectively record all primary central nervous system tumor (PCNST) cases in France, for which histological diagnosis is available. The objectives were to (i) create a national registry and a network to perform epidemiological studies; (ii) implement clinical and basic research protocols; and (iii) harmonize the health care of patients affected by PCNST. For 5 years, 25 756 cases of newly diagnosed and histologically confirmed PCNST have been recorded. Histological diagnoses included glioma (48.9%), all other neuroepithelial tumors (5%), meningioma (28.8%), nerve sheath tumors (8.4%), lymphoma (3.2%) and others (5.7%). Cryopreservation was reported for 6018 PCNST specimens. Tumor resections (R) were performed in 78% cases, while biopsies accounted for 22%. Median age (MA), sex, percentage R and number of cryopreserved tumors were detailed for each histology; for example, out of 6053 glioblastomas (MA 63 years, male 59.4%, R 62%, 1611 were cryopreserved), and out of 37 atypical teratoid/rhabdoid tumors (MA 2 years, male 56.8%, R 94%, 17 were cryopreserved). This database or databank dedicated to PCNST cases contains detailed data on clinical, histological and other characteristics, such as the inclusion of data on cryopreserved specimens that are not available in other European registries. Therefore, this is a valuable resource that can be used for planning future epidemiological and clinical research.
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