期刊
BRAIN IMAGING AND BEHAVIOR
卷 14, 期 1, 页码 51-61出版社
SPRINGER
DOI: 10.1007/s11682-018-9970-5
关键词
Midlife cardiovascular risk factors; Framingham cardiovascular risk profile score; White matter hyperintensity volume; Cognitive domains; Elderly women
类别
资金
- National Health and Medical Research Council (NHMRC) [547500, 1032350, 1062133]
- Ramaciotti Foundation
- Australian Healthy Ageing Organisation
- Brain Foundation
- Alzheimer's Association [NIA320312]
- Australian Menopausal Society
- Bayer Healthcare
- Shepherd Foundation
- Scobie and Claire Mackinnon Foundation
- Collier Trust Fund
- J. O. & J.R. Wicking Trust
- Mason Foundation
- Alzheimer's Association of Australia
- VicHealth
- NHMRC
- National Health and Medical Research Council
Cerebral White Matter Hyperintensity (WMH) lesions have been identified as markers of cerebrovascular diseases and they are associated with increased risk of cognitive impairment. In this study, we investigated the relationship between midlife cardiovascular risk factors and late life WMH volumes two decades later, and examined their association with cognitive performance. 135 participants from the Women's Healthy Ageing Project had completed midlife cardiovascular risk measurement in 1992 and late life brain MRI scan and cognitive assessment in 2012. In these community-dwelling normal aging women, we found that higher midlife Framingham Cardiovascular Risk Profile (FCRP) score was associated with greater WMH volume two decades later, and was predominantly driven by the impact of HDL cholesterol level, controlling for age, education and APOE epsilon 4 status. Structural equation modelling demonstrated that the relationship between midlife FCRP score and late life executive function was mediated by WMH volume. These findings suggest intervention strategies that target major cardiovascular risk factors at midlife might be effective in reducing the development of WMH lesions and thus late life cognitive decline.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据