期刊
BRAIN IMAGING AND BEHAVIOR
卷 6, 期 4, 页码 528-539出版社
SPRINGER
DOI: 10.1007/s11682-012-9190-3
关键词
ADNI; Neuropsychology; Cognition; Cognitive change; Confirmatory factor analysis
类别
资金
- National Institute on Aging [R13AG030995, P01 AG031720, AG036694, AG027171, K01 AG034175, R01 AG031252, AG022538, AG028786, AG037212]
- National Institutes of Health [T32 AG023480]
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering
- Canadian Institutes of Health Research
- NIH [P30 AG010129, K01 AG030514]
- Dana Foundation
The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a large multi-center study designed to develop optimized methods for acquiring longitudinal neuroimaging, cognitive, and biomarker measures of AD progression in a large cohort of patients with Alzheimer's disease (AD), patients with Mild Cognitive Impairment, and healthy controls. Detailed neuropsychological testing was conducted on all participants. We examined the factor structure of the ADNI Neuropsychological Battery across older adults with differing levels of clinical AD severity based on the Clinical Dementia Rating Scale (CDR). Confirmatory factor analysis (CFA) of 23 variables from 10 neuropsychological tests resulted in five factors (memory, language, visuospatial functioning, attention, and executive function/processing speed) that were invariant across levels of cognitive impairment. Thus, these five factors can be used as indicators of cognitive function in older adults who are participants in ADNI.
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