期刊
BRAIN IMAGING AND BEHAVIOR
卷 5, 期 4, 页码 252-261出版社
SPRINGER
DOI: 10.1007/s11682-011-9129-0
关键词
Olfactory sulcus; Olfactory bulb; Schizophrenia; Smell identification; Olfaction; Neuroimaging
类别
资金
- VA Merit Awards
- VA Schizophrenia Center
- National Institute of Mental Health [MH 070047, MH 50740]
- NIH Mental Health Center for Clinical Interventional Development and Applied Research [P50 11P50 MH 080272]
The current report used structural magnetic resonance imaging (MRI) to objectively measure olfactory bulb volume and olfactory sulcal depth in patients diagnosed with chronic schizophrenia and healthy controls. Additional measures were obtained to assess olfactory function. The olfactory bulb and sulcus were manually traced on structural 3T MRIs for 25 right-handed male patients diagnosed with chronic schizophrenia and 25 matched male healthy controls. A sub-set of subjects received the University of Pennsylvania Smell Identification Test (UPSIT). Olfactory bulb volume was significantly decreased in patients with schizophrenia compared to healthy controls, as was their performance on the UPSIT. Additionally, a positive correlation was seen in patients between right bulb volume and UPSIT scores. Overall, our findings support earlier research studies showing morphometric and functional changes in the olfactory system in patients with schizophrenia.
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